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Technical NotesExploring CIMac PrimaS™ for Purity Analysis of mRNA

CIMac PrimaS is a new member of BIA’s family of high performance chromatography products for analysis and purification of mRNA. Its positive charge gives it some anion exchange behavior but hydrogen ...

Technical NotesMethod development on CIM H-Bond monoliths

H-Bond ADC is the first of a new class of chromatography ligands from BIA separations that exploits hydrogen bonding as the dominant mode of biomolecule retention. The ligand consists of a terminal se ...

Technical NotesChemical Stability of CIMac™ Analytical Columns

The stability of QA, DEAE and SO3 CIMac™ Analytical Columns was tested according to the CIP (Cleaning In Place) procedures described in the respective Product Specification Sheets (see Table 1). We ...

Technical NotesLifetime Stability of CIMac™ pDNA Analytical Column

One of the key steps in purification of plasmid DNA vaccines for therapeutic use is the separation of supercoiled (SC) and open circular (OC) conformations of plasmid DNA. In order to monitor product ...

Technical NotesPurification of mRNA with CIMmultus™ C4 HLD

CIMmultus C4 HLD is a hydrophobic interaction chromatography monolith for purification of nucleic acids. Sample is applied at high ionic strength in salts that precipitate RNA. The column is eluted wi ...